Lentiviral human COX4I1 sgRNA gene knockout kit

Human COX4I1

Gene symbol: COX4I1
Synonyms: COX IV-1 COX4 COX4-1 COXIV COXIV-1
Species: HUMAN
Gene ID: 1327
Summary: Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit IV isoform 1 of the human mitochondrial respiratory chain enzyme. It is located at the 3' of the NOC4 (neighbor of COX4) gene in a head-to-head orientation, and shares a promoter with it. Pseudogenes related to this gene are located on chromosomes 13 and 14. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_001861:4:3 NM_001318786:4:3 NM_001318788:4:3 NM_001318794:4:3 NM_001318797:4:2 NM_001318802:4:2