Lentiviral human COL27A1 sgRNA gene knockout kit

Human COL27A1

Gene symbol: COL27A1
Synonyms: STLS
Species: HUMAN
Gene ID: 85301
Summary: This gene encodes a member of the fibrillar collagen family, and plays a role during the calcification of cartilage and the transition of cartilage to bone. The encoded protein product is a preproprotein. It includes an N-terminal signal peptide, which is followed by an N-terminal propetide, mature peptide and a C-terminal propeptide. The N-terminal propeptide contains thrombospondin N-terminal-like and laminin G-like domains. The mature peptide is a major triple-helical region. The C-terminal propeptide, also known as COLFI domain, plays crucial roles in tissue growth and repair. Mutations in this gene cause Steel syndrome. Alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been determined. [provided by RefSeq, Sep 2014].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_032888:3:3