Lentiviral human COL11A2 sgRNA gene knockout kit

Human COL11A2

Gene symbol: COL11A2
Synonyms: DFNA13 DFNB53 FBCG2 HKE5 OSMEDA OSMEDB PARP STL3
Species: HUMAN
Gene ID: 1302
Summary: This gene encodes one of the two alpha chains of type XI collagen, a minor fibrillar collagen. It is located on chromosome 6 very close to but separate from the gene for retinoid X receptor beta. Type XI collagen is a heterotrimer but the third alpha chain is a post-translationally modified alpha 1 type II chain. Proteolytic processing of this type XI chain produces PARP, a proline/arginine-rich protein that is an amino terminal domain. Mutations in this gene are associated with type III Stickler syndrome, otospondylomegaepiphyseal dysplasia (OSMED syndrome), Weissenbacher-Zweymuller syndrome, autosomal dominant non-syndromic sensorineural type 13 deafness (DFNA13), and autosomal recessive non-syndromic sensorineural type 53 deafness (DFNB53). Alternative splicing results in multiple transcript variants. A related pseudogene is located nearby on chromosome 6. [provided by RefSeq, Jul 2009].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_080680:3:3 NM_080681:3:3 NM_080679:3:3 NM_001163771:3:3