Lentiviral human CISH sgRNA gene knockout kit

Human CISH

Gene symbol: CISH
Synonyms: BACTS2 CIS CIS-1 G18 SOCS
Species: HUMAN
Gene ID: 1154
Summary: The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_013324:3:2 NM_145071:2:2