Lentiviral human CILP sgRNA gene knockout kit

Human CILP

Gene symbol: CILP
Synonyms: CILP-1 HsT18872
Species: HUMAN
Gene ID: 8483
Summary: Major alterations in the composition of the cartilage extracellular matrix occur in joint disease, such as osteoarthrosis. This gene encodes the cartilage intermediate layer protein (CILP), which increases in early osteoarthrosis cartilage. The encoded protein was thought to encode a protein precursor for two different proteins; an N-terminal CILP and a C-terminal homolog of NTPPHase, however, later studies identified no nucleotide pyrophosphatase phosphodiesterase (NPP) activity. The full-length and the N-terminal domain of this protein was shown to function as an IGF-1 antagonist. An allelic variant of this gene has been associated with lumbar disc disease. [provided by RefSeq, Sep 2010].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_003613:4:3