Lentiviral human CHRNA3 sgRNA gene knockout kit

Human CHRNA3

Gene symbol: CHRNA3
Synonyms: LNCR2 NACHRA3 PAOD2
Species: HUMAN
Gene ID: 1136
Summary: This locus encodes a member of the nicotinic acetylcholine receptor family of proteins. Members of this family of proteins form pentameric complexes comprised of both alpha and beta subunits. This locus encodes an alpha-type subunit, as it contains characteristic adjacent cysteine residues. The encoded protein is a ligand-gated ion channel that likely plays a role in neurotransmission. Polymorphisms in this gene have been associated with an increased risk of smoking initiation and an increased susceptibility to lung cancer. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2009].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_000743:5:5 NM_001166694:5:5