Lentiviral human CGGBP1 sgRNA gene knockout kit

Human CGGBP1

Gene symbol: CGGBP1
Synonyms: CGGBP p20-CGGBP
Species: HUMAN
Gene ID: 8545
Summary: This gene encodes a CGG repeat-binding protein that primarily localizes to the nucleus. CGG trinucleotide repeats are implicated in many disorders as they often act as transcription- and translation-regulatory elements, can produce hairpin structures which cause DNA replication errors, and form regions prone to chromosomal breakage. CGG repeats are also targets for CpG methylation. In addition to its ability to bind CGG repeats and regulate transcription, this gene is believed to play a role in DNA damage repair and telomere protection. In vitro studies indicate this protein does not bind to methylated CpG sequences. [provided by RefSeq, Jul 2017].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_001008390:4:1 NM_003663:3:1 NM_001195308:4:1