Lentiviral human CEP290 sgRNA gene knockout kit

Human CEP290

Gene symbol: CEP290
Synonyms: 3H11Ag BBS14 CT87 JBTS5 LCA10 MKS4 NPHP6 POC3 rd16 SLSN6
Species: HUMAN
Gene ID: 80184
Summary: This gene encodes a protein with 13 putative coiled-coil domains, a region with homology to SMC chromosome segregation ATPases, six KID motifs, three tropomyosin homology domains and an ATP/GTP binding site motif A. The protein is localized to the centrosome and cilia and has sites for N-glycosylation, tyrosine sulfation, phosphorylation, N-myristoylation, and amidation. Mutations in this gene have been associated with Joubert syndrome and nephronophthisis and the presence of antibodies against this protein is associated with several forms of cancer. [provided by RefSeq, Jul 2008].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_025114:25:24