Lentiviral human CEP104 sgRNA gene knockout kit

Human CEP104

Gene symbol: CEP104
Synonyms: CFAP256 GlyBP JBTS25 KIAA0562 ROC22
Species: HUMAN
Gene ID: 9731
Summary: This gene encodes a centrosomal protein required for ciliogenesis and for ciliary tip structural integrity. The mammalian protein contains three amino-terminal hydrophobic domains, two glycosylation sites, four cysteine-rich motifs, and two regions with homology to the glutamate receptor ionotropic, NMDA 1 protein. During ciliogenesis, the encoded protein translocates from the distal tips of the centrioles to the tip of the elongating cilium. Knockdown of the protein in human retinal pigment cells results in severe defects in ciliogenesis with structural deformities at the ciliary tips. Allelic variants of this gene are associated with the autosomal-recessive disorder Joubert syndrome, which is characterized by a distinctive mid-hindbrain and cerebellar malformation, oculomotor apraxia, irregular breathing, developmental delay, and ataxia. [provided by RefSeq, Feb 2016].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_014704:8:7