Lentiviral human CENPJ sgRNA gene knockout kit

Human CENPJ

Gene symbol: CENPJ
Synonyms: BM032 CENP-J CPAP LAP LIP1 MCPH6 Sas-4 SASS4 SCKL4
Species: HUMAN
Gene ID: 55835
Summary: This gene encodes a protein that belongs to the centromere protein family. During cell division, this protein plays a structural role in the maintenance of centrosome integrity and normal spindle morphology, and it is involved in microtubule disassembly at the centrosome. This protein can function as a transcriptional coactivator in the Stat5 signaling pathway, and also as a coactivator of NF-kappaB-mediated transcription, likely via its interaction with the coactivator p300/CREB-binding protein. Mutations in this gene are associated with primary autosomal recessive microcephaly, a disorder characterized by severely reduced brain size and cognitive disability. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_018451:2:1