Lentiviral human CDKN1B sgRNA gene knockout kit

Human CDKN1B

Gene symbol: CDKN1B
Synonyms: CDKN4 KIP1 MEN1B MEN4 P27KIP1
Species: HUMAN
Gene ID: 1027
Summary: This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). [provided by RefSeq, Apr 2014].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_004064:1:1