Lentiviral human CDH4 sgRNA gene knockout kit

Human CDH4

Gene symbol: CDH4
Synonyms: CAD4 R-CAD RCAD
Species: HUMAN
Gene ID: 1002
Summary: This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_001794:4:4 NM_001252338:3:3 NM_001252339:3:2