Lentiviral human CD3D sgRNA gene knockout kit

Human CD3D

Gene symbol: CD3D
Synonyms: CD3-DELTA IMD19 T3D
Species: HUMAN
Gene ID: 915
Summary: The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined. [provided by RefSeq, Feb 2009].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_000732:2:2 NM_001040651:2:2