Lentiviral human CCM2 sgRNA gene knockout kit

Human CCM2

Gene symbol: CCM2
Synonyms: C7orf22 OSM PP10187
Species: HUMAN
Gene ID: 83605
Summary: This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2009].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_001029835:4:4 NM_031443:4:4 NM_001363458:4:4 NM_001363459:3:3 NM_001167934:3:3 NM_001167935:4:4