Lentiviral human CCDC88A sgRNA gene knockout kit

Human CCDC88A

Gene symbol: CCDC88A
Synonyms: APE GIRDIN GIV GRDN HkRP1 KIAA1212 PEHO PEHOL
Species: HUMAN
Gene ID: 55704
Summary: This gene encodes a member of the Girdin family of coiled-coil domain containing proteins. The encoded protein is an actin-binding protein that is activated by the serine/threonine kinase Akt and plays a role in cytoskeleton remodeling and cell migration. The encoded protein also enhances Akt signaling by mediating phosphoinositide 3-kinase (PI3K)-dependent activation of Akt by growth factor receptor tyrosine kinases and G protein-coupled receptors. Increased expression of this gene and phosphorylation of the encoded protein may play a role in cancer metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_001135597:8:8 NM_018084:8:8 NM_001254943:8:8 NM_001365480:8:8