Lentiviral human CAST sgRNA gene knockout kit

Human CAST

Gene symbol: CAST
Synonyms: BS-17 PLACK
Species: HUMAN
Gene ID: 831
Summary: The protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_001750:16:16 NM_173060:13:12 NM_001042440:14:14 NM_001042441:15:15 NM_001042442:15:15 NM_001042443:14:13 NM_001042444:12:11 NM_001042445:12:11 NM_001042446:11:10 NM_001284212:12:11 NM_001284213:11:10 NM_001190442:15:12 NM_001330626:14:14 NM_001330627:14:14 NM_001330628:14:14 NM_001330629:15:15 NM_001330630:11:10 NM_001330631:13:12 NM_001330632:13:12 NM_001330633:13:12 NM_001330634:12:11 NM_001375317:15:15