Lentiviral human CASP10 sgRNA gene knockout kit

Human CASP10

Gene symbol: CASP10
Synonyms: ALPS2 FLICE2 MCH4
Species: HUMAN
Gene ID: 843
Summary: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_032977:2:1 NM_032974:2:1 NM_001230:2:1 NM_032976:2:1 NM_001206542:2:1 NM_001206524:2:1 NM_001306083:2:1