Lentiviral human CAPN6 sgRNA gene knockout kit

Human CAPN6

Gene symbol: CAPN6
Synonyms: CalpM CANPX CAPNX DJ914P14.1
Species: HUMAN
Gene ID: 827
Summary: Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is highly expressed in the placenta. Its C-terminal region lacks any homology to the calmodulin-like domain of other calpains. The protein lacks critical active site residues and thus is suggested to be proteolytically inactive. The protein may play a role in tumor formation by inhibiting apoptosis and promoting angiogenesis. [provided by RefSeq, Nov 2009].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_014289:5:4