Lentiviral human CAD sgRNA gene knockout kit

Human CAD

Gene symbol: CAD
Synonyms: CDG1Z EIEE50 GATD4
Species: HUMAN
Gene ID: 790
Summary: The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_004341:20:20 NM_001306079:19:19