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Overview
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Kit Components: Lentiviral particles or plasmids for a set of three sgRNAs, and a pair of Indel screening PCR primers
sgRNA lentiviral particle information
• Functional titer: 1x10^8 TU/ml
• Titration method: counting puromycin resistant cell clones
• Purity: In vivo grade
• Pseudotype: VSVG
• Storage buffer: LentiShield™ lentivirus storage buffer
• Storage: condition -80°C
• Availability: 3-5 weeks
sgRNA lentiviral plasmid information
• Promoter for target sgRNA: U6
• Mammalian selection: puromycin
• Promoter for mammalian selection gene: EF1a
• E.coli selection: Amp
• Storage condition: -20°C
• Availability: 1-2 weeksPlease contact us at for specific academic pricing.
Target Information
Target NameHuman CACNA1CAbout TargetGene symbol: CACNA1C
Synonyms: CACH2 CACN2 CACNL1A1 CaV1.2 CCHL1A1 LQT8 TS TS. LQT8
Species: HUMAN
Gene ID: 775
Summary: This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins. Some of the predicted proteins may not produce functional ion channel subunits. [provided by RefSeq, Oct 2012].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_199460:6:6 NM_000719:6:6 NM_001129827:6:6 NM_001129829:6:6 NM_001129830:6:6 NM_001129831:6:6 NM_001129832:6:6 NM_001129833:6:6 NM_001129834:6:6 NM_001129835:6:6 NM_001129836:6:6 NM_001129837:6:6 NM_001129838:6:6 NM_001129839:6:6 NM_001129840:6:6 NM_001129841:6:6 NM_001129842:6:6 NM_001129843:6:6 NM_001129844:6:6 NM_001129846:6:6 NM_001167623:6:6 NM_001167624:6:6 NM_001167625:6:6
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