Lentiviral human CA8 sgRNA gene knockout kit

Human CA8

Gene symbol: CA8
Synonyms: CA-RP CA-VIII CALS CAMRQ3 CARP
Species: HUMAN
Gene ID: 767
Summary: The protein encoded by this gene was initially named CA-related protein because of sequence similarity to other known carbonic anhydrase genes. However, the gene product lacks carbonic anhydrase activity (i.e., the reversible hydration of carbon dioxide). The gene product continues to carry a carbonic anhydrase designation based on clear sequence identity to other members of the carbonic anhydrase gene family. The absence of CA8 gene transcription in the cerebellum of the lurcher mutant in mice with a neurologic defect suggests an important role for this acatalytic form. Mutations in this gene are associated with cerebellar ataxia, mental retardation, and dysequilibrium syndrome 3 (CMARQ3). Polymorphisms in this gene are associated with osteoporosis, and overexpression of this gene in osteosarcoma cells suggests an oncogenic role. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_004056:2:2 NM_001321837:2:2 NM_001321838:2:2 NM_001321839:2:2