Lentiviral human C3 sgRNA gene knockout kit

Human C3

Gene symbol: C3
Synonyms: AHUS5 ARMD9 ASP C3a C3b CPAMD1 HEL-S-62p
Species: HUMAN
Gene ID: 718
Summary: Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form the mature protein, which is then further processed to generate numerous peptide products. The C3a peptide, also known as the C3a anaphylatoxin, modulates inflammation and possesses antimicrobial activity. Mutations in this gene are associated with atypical hemolytic uremic syndrome and age-related macular degeneration in human patients. [provided by RefSeq, Nov 2015].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_000064:11:11