Lentiviral human BRCA2 sgRNA gene knockout kit

Human BRCA2

Gene symbol: BRCA2
Synonyms: BRCC2 BROVCA2 FACD FAD FAD1 FANCD FANCD1 GLM3 PNCA2 XRCC11
Species: HUMAN
Gene ID: 675
Summary: Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq, Dec 2008].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_000059:3:2