Lentiviral human BCL6 sgRNA gene knockout kit

Human BCL6

Gene symbol: BCL6
Synonyms: BCL5 BCL6A LAZ3 ZBTB27 ZNF51
Species: HUMAN
Gene ID: 604
Summary: The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2015].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_001706:5:3