Lentiviral human BAP1 sgRNA gene knockout kit

Human BAP1

Gene symbol: BAP1
Synonyms: HUCEP-13 hucep-6 UCHL2
Species: HUMAN
Gene ID: 8314
Summary: This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, uveal melanoma and cutaneous melanoma. [provided by RefSeq, May 2013].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_004656:5:5