Lentiviral human ATG4D sgRNA gene knockout kit

Human ATG4D

Gene symbol: ATG4D
Synonyms: APG4-D APG4D AUTL4
Species: HUMAN
Gene ID: 84971
Summary: Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene belongs to the autophagy-related protein 4 (Atg4) family of C54 endopeptidases. Members of this family encode proteins that play a role in the biogenesis of autophagosomes, which sequester the cytosol and organelles for degradation by lysosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_032885:3:3 NM_001281504:3:2