Lentiviral human ARNT sgRNA gene knockout kit

Human ARNT

Gene symbol: ARNT
Synonyms: bHLHe2 HIF-1-beta HIF-1beta HIF1-beta HIF1B HIF1BETA TANGO
Species: HUMAN
Gene ID: 405
Summary: This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1. Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_001668:14:14 NM_178427:13:13 NM_001197325:13:13 NM_001286035:15:13 NM_001286036:14:14 NM_001350224:15:13 NM_001350225:14:13 NM_001350226:14:13