Lentiviral human ARHGEF11 sgRNA gene knockout kit

Human ARHGEF11

Gene symbol: ARHGEF11
Synonyms: GTRAP48 PDZ-RHOGEF
Species: HUMAN
Gene ID: 9826
Summary: Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_014784:24:24 NM_198236:25:25