Lentiviral human APC sgRNA gene knockout kit

Human APC

Gene symbol: APC
Synonyms: BTPS2 DP2 DP2.5 DP3 GS PPP1R46
Species: HUMAN
Gene ID: 324
Summary: This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Jul 2008].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_001127511:14:14