Lentiviral human ALPL sgRNA gene knockout kit

Human ALPL

Gene symbol: ALPL
Synonyms: AP-TNAP APTNAP HOPS TNALP TNAP TNSALP
Species: HUMAN
Gene ID: 249
Summary: This gene encodes a member of the alkaline phosphatase family of proteins. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme may play a role in bone mineralization. Mutations in this gene have been linked to hypophosphatasia, a disorder that is characterized by hypercalcemia and skeletal defects. [provided by RefSeq, Oct 2015].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_000478:5:4 NM_001127501:4:3 NM_001369803:5:4 NM_001369804:5:4 NM_001369805:5:4 NM_001177520:3:2