Lentiviral human ALDH18A1 sgRNA gene knockout kit

Human ALDH18A1

Gene symbol: ALDH18A1
Synonyms: ADCL3 ARCL3A GSAS P5CS PYCS SPG9 SPG9A SPG9B
Species: HUMAN
Gene ID: 5832
Summary: This gene is a member of the aldehyde dehydrogenase family and encodes a bifunctional ATP- and NADPH-dependent mitochondrial enzyme with both gamma-glutamyl kinase and gamma-glutamyl phosphate reductase activities. The encoded protein catalyzes the reduction of glutamate to delta1-pyrroline-5-carboxylate, a critical step in the de novo biosynthesis of proline, ornithine and arginine. Mutations in this gene lead to hyperammonemia, hypoornithinemia, hypocitrullinemia, hypoargininemia and hypoprolinemia and may be associated with neurodegeneration, cataracts and connective tissue diseases. Alternatively spliced transcript variants, encoding different isoforms, have been described for this gene. [provided by RefSeq, Jul 2008].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_002860:9:8 NM_001017423:9:8 NM_001323412:8:6 NM_001323413:9:8 NM_001323414:9:8 NM_001323415:9:8 NM_001323416:8:6 NM_001323417:8:7 NM_001323418:8:6 NM_001323419:6:4