Lentiviral human AKAP13 sgRNA gene knockout kit

Human AKAP13

Gene symbol: AKAP13
Synonyms: AKAP-13 AKAP-Lbc ARHGEF13 BRX c-lbc HA-3 Ht31 LBC p47 PRKA13 PROTO-LB PROTO-LBC
Species: HUMAN
Gene ID: 11214
Summary: The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms containing c-terminal dbl oncogene homology (DH) and pleckstrin homology (PH) domains. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway, function as protein kinase A-anchoring proteins and, in addition, enhance ligand-dependent activity of estrogen receptors alpha and beta. [provided by RefSeq, Jul 2012].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_006738:11:10 NM_007200:11:10 NM_001270546:4:4