Lentiviral human ADGRL1 sgRNA gene knockout kit

Human ADGRL1

Gene symbol: ADGRL1
Synonyms: CIRL1 CL1 LEC2 LPHN1
Species: HUMAN
Gene ID: 22859
Summary: This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Oct 2008].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_001008701:6:5