Lentiviral human ADGRE5 sgRNA gene knockout kit

Human ADGRE5

Gene symbol: ADGRE5
Synonyms: CD97 TM7LN1
Species: HUMAN
Gene ID: 976
Summary: This gene encodes a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors, which mediate cell-cell interactions. These proteins are cleaved by self-catalytic proteolysis into a large extracellular subunit and seven-span transmembrane subunit, which associate at the cell surface as a receptor complex. The encoded protein may play a role in cell adhesion as well as leukocyte recruitment, activation and migration, and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55. Expression of this gene may play a role in the progression of several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like repeats have been observed for this gene. This gene is found in a cluster with other EGF-TM7 genes on the short arm of chromosome 19. [provided by RefSeq, Jun 2011].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_078481:10:10 NM_001025160:9:9 NM_001784:8:8