Lentiviral human ADAMTSL2 sgRNA gene knockout kit

Human ADAMTSL2

Gene symbol: ADAMTSL2
Synonyms: ADAMTSL-2 GPHYSD1
Species: HUMAN
Gene ID: 9719
Summary: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) and ADAMTS-like protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene lacks the protease domain, and is therefore of a member of the the ADAMTS-like protein subfamily. It is a secreted glycoprotein that binds the cell surface and extracellular matrix; it also interacts with latent transforming growth factor beta binding protein 1. Mutations in this gene have been associated with geleophysic dysplasia. [provided by RefSeq, Feb 2009].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_014694:9:8