Lentiviral human ADAMTS18 sgRNA gene knockout kit

Human ADAMTS18

Gene symbol: ADAMTS18
Synonyms: ADAMTS21 KNO2 MMCAT
Species: HUMAN
Gene ID: 170692
Summary: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protein, which may regulate hemostatic balance and function as a tumor suppressor. Mutations in this gene may be associated with microcornea, myopic chorioretinal atrophy, and telecanthus (MMCAT) and cone-rod dystrophy in human patients. [provided by RefSeq, May 2016].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_199355:12:12 NM_001326358:12:9