Lentiviral human ACVRL1 sgRNA gene knockout kit

Human ACVRL1

Gene symbol: ACVRL1
Synonyms: ACVRLK1 ALK-1 ALK1 HHT HHT2 ORW2 SKR3 TSR-I
Species: HUMAN
Gene ID: 94
Summary: This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2. [provided by RefSeq, Jul 2008].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_000020:3:2 NM_001077401:2:2