Lentiviral human ACVR1 sgRNA gene knockout kit

Human ACVR1

Gene symbol: ACVR1
Synonyms: ACTRI ACVR1A ACVRLK2 ALK2 FOP SKR1 TSRI
Species: HUMAN
Gene ID: 90
Summary: Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. [provided by RefSeq, Jul 2008].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_001105:5:3 NM_001111067:5:3 NM_001347663:5:3 NM_001347664:6:3 NM_001347665:6:3 NM_001347666:6:3 NM_001347667:6:3