Lentiviral human ACTN2 sgRNA gene knockout kit

Human ACTN2

Gene symbol: ACTN2
Synonyms: CMD1AA CMH23 MPD6 MYOCOZ
Species: HUMAN
Gene ID: 88
Summary: Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_001103:12:12 NM_001278343:12:12 NM_001278344:14:6