Lentiviral human ACLY sgRNA gene knockout kit

Human ACLY

Gene symbol: ACLY
Synonyms: ACL ATPCL CLATP
Species: HUMAN
Gene ID: 47
Summary: ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2014].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_001096:5:4 NM_198830:5:4 NM_001303274:5:5 NM_001303275:5:5