Lentiviral human ABI1 sgRNA gene knockout kit

Human ABI1

Gene symbol: ABI1
Synonyms: ABI-1 ABLBP4 E3B1 NAP1BP SSH3BP SSH3BP1
Species: HUMAN
Gene ID: 10006
Summary: This gene encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein complexes, and regulate actin polymerization and cytoskeletal remodeling through interactions with Abelson tyrosine kinases. The encoded protein plays a role in macropinocytosis as a component of the WAVE2 complex, and also forms a complex with EPS8 and SOS1 that mediates signal transduction from Ras to Rac. This gene may play a role in the progression of several malignancies including melanoma, colon cancer and breast cancer, and a t(10;11) chromosomal translocation involving this gene and the MLL gene has been associated with acute myeloid leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 14. [provided by RefSeq, Sep 2011].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_005470:5:5 NM_001012750:5:5 NM_001012751:5:5 NM_001012752:4:4 NM_001178116:6:6 NM_001178119:5:5 NM_001178120:5:5 NM_001178121:4:4 NM_001178122:5:5 NM_001178123:5:5 NM_001178124:4:4 NM_001178125:3:3 NM_001348029:5:5 NM_001348030:4:4 NM_001348031:5:5 NM_001348032:5:5 NM_001348033:5:5 NM_001348034:5:5