Lentiviral human ABCG2 sgRNA gene knockout kit

Human ABCG2

Gene symbol: ABCG2
Synonyms: ABC15 ABCP BCRP BCRP1 BMDP CD338 CDw338 EST157481 GOUT1 MRX MXR MXR-1 MXR1 UAQTL1
Species: HUMAN
Gene ID: 9429
Summary: The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_004827:7:6 NM_001257386:7:6 NM_001348985:8:6 NM_001348986:7:6 NM_001348987:7:6 NM_001348988:8:6 NM_001348989:7:6