Lentiviral human ABCB1 sgRNA gene knockout kit

Human ABCB1

Gene symbol: ABCB1
Synonyms: ABC20 CD243 CLCS GP170 MDR1 P-GP PGY1
Species: HUMAN
Gene ID: 5243
Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Feb 2017].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_001348945:10:8 NM_001348944:8:5 NM_000927:7:5 NM_001348946:6:5