Lentiviral human ABCA1 sgRNA gene knockout kit

Human ABCA1

Gene symbol: ABCA1
Synonyms: ABC-1 ABC1 CERP HDLCQTL13 HDLDT1 HPALP1 TGD
Species: HUMAN
Gene ID: 19
Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in both alleles of this gene cause Tangier disease and familial high-density lipoprotein (HDL) deficiency. [provided by RefSeq, Sep 2019].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_005502:4:3