Latrunculin B

- Overview
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    Background
    
    Latrunculin B is a cell-permeable actin polymerization inhibitor in vitro and in vivo by the formation of a 1:1 complex with monomeric G-actin[1].
    Although the activity of latrunculin B is slightly weaker than latrunculin A, its short-term effect is comparable to latrunculin A. The presence of serum in the medium always containing latrunculin B gradually causes the inactivation of latrunculin B, so that the induced changes are instantaneous. Because of this, latrunculin B may produce fewer undesirable physiological effects than latrunculin A, making it more suitable for short-term studies[2].
    
    [1]. Wakatsuki T, Schwab B, Thompson N C, et al. Effects of cytochalasin D and latrunculin B on mechanical properties of cells. Journal of Cell Science, 2000, 114(5): 1025-1036.
    [2]. Spector I, Schochet N R, Blasberger D, et al. Latrunculins-novel marine macrolides that disrupt microfilament organization and affect cell growth: I. comparison with cytochalasin D. Cell Motility and the Cytoskeleton, 1989, 13(3): 127-144.
- Properties
  - Categories
    
    F-actin–destabilizing agent
    
    Alternative Name
    
    4R-[(1R,4Z,8Z,10S,13R,15R)-15-hydroxy-5,10-dimethyl-3-oxo-2,14-dioxabicyclo[11.3.1]heptadeca-4,8-dien-15-yl]-2-thiazolidinone
    
    CAS Number
    
    76343-94-7
    
    Molecular Formula
    
    C20H29NO5S
    
    Molecular Weight
    
    395.5
    
    Appearance
    
    Colourless film
    
    Purity
    
    Purity ≥ 97.00%
    
    Solubility
    
    ≤25mg/ml in DMSO
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    C/C(CC/C=C\[[email protected]@H](C)CC[[email protected]@H]1C[[email protected]@H]2C[[email protected]@]([[email protected]]3N([H])C(SC3)=O)(O)O1)=C/C(O2)=O
    
    * For Research Use Only
- Reference
  - 1. Wang H, Liu W, et al. "Inhibitor analysis revealed that clathrin-mediated endocytosis is involed in cellular entry of type III grass carp reovirus." Virol J. 2018 May 24;15(1):92. PMID:29793525

Documents

COA (Certificate Of Analysis)

MSDS (Material Safety Data Sheet)

Latrunculin B

Background

Documents

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