Krytopyrrole Colorimetric Assay

Kryptopyrrole appears in the urine of patients undergoing severe physiological or psychological stress. The 2,4 dimethyl-3-ethylpyrrole is a byproduct of hemoglobin synthesis. The presence of urinary kryptopyrrole (mauve factor) was first reported in patients with LSD psychosis. High levels were also found in the urine of schizophrenic patients.It has been found out that circulating kryptopyrrole forms a Shiff base with the aldehyde form of vitamin B6 (pyridoxal 5 phosphate) in the blood. This combination then binds with zinc and builds an unsoluble complex. As large amounts of kryptopyrroles are excreted in the urine, it depletes the blood of B6 and zinc. The reason for increased kryptopyrrol synthesis might be an inborn error of the pyrrole chemistry or a disorder incuced by environmental conditions or stress.
The Krytopyrrole Colorimetric Assay is for Research Use Only. The Krytopyrrole Colorimetric Assay is not for use in diagnostic procedures.

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