KPNA2 Polyclonal Antibody (1.08 mg/mL) for IHC, ELISA

KPNA2 Polyclonal Antibody (1.08 mg/mL) for IHC, ELISA

Catalog Number:
A001508454RED
Mfr. No.:
RD252984A
Price:
$253
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      • Overview
        • Gene Accession: BC005978

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          Background

          The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination. Alternative splicing results in multiple transcript variants.

      • Properties
        • Host
          rabbit
          Antibody Type
          polyclonal
          Isotype
          IgG
          Reactivity
          human; mouse
          Immunogen
          Fusion protein of human KPNA2
          Purification
          Antigen affinity purification
          Conjugate
          Unconjugated
          Formulation
          PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
          Storage
          Store at -20°C. Avoid freeze-thaw cycles.
          Concentration
          1.08 mg/mL
          Antigen
          IMA1, Importin alpha 1, Importin alpha 2, Importin alpha 2 subunit, Importin alpha P1, Importin subunit alpha-1, IPO A1, IPOA 1, IPOA1, Karyopherin alpha 2, Karyopherin alpha 2 RAG cohort 1, Karyopherin alpha 2 subunit, Karyopherin subunit alpha-2, KPNA2, KPNA2 protein, Pendulin, QIP 2, QIP2, RAG cohort 1, RAG cohort protein 1, RCH 1, RCH1, SRP 1, SRP1 alpha, SRP1, SRP1-alpha, SRP1alpha (UniProt:P52292)

          * For reference only.

      • Applications
        • Application
          IHC; ELISA
        • Application Dilutions
          IHC 1:50-1:300
          ELISA 1:5000-1:10000

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