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KN-92

KN-92

Catalog Number:
L002368709APE
Mfr. No.:
APE-A3529
Price:
$409
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      • Overview

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          Background

          KN-92 is an inactive derivative of KN-93. It is intended to be used as a control compound in studies designed to elucidate the antagonist activities of KN-93. KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM). KN-93 inhibits histamine-induced aminopyrine uptake in parietal cells (IC50 = 300 nM). KN-93 has been used to implicate roles for CaMKII in Ca2+-induced Ca2+ release in cardiac myocytes, constitutive phosphorylation of 5-lipoxygenase in 3T3 cells, and Ca2+-dependent activation of HIF-1α in colon cancer cell.

      • Properties
        • Alternative Name
          KN 92;KN92; (E)-N-(2-(((3-(4-chlorophenyl)allyl)(methyl)amino)methyl)phenyl)-4-methoxybenzenesulfonamide
          CAS Number
          176708-42-2
          Molecular Formula
          C24H25ClN2O3S
          Molecular Weight
          456.98
          Appearance
          A yellow oil
          Purity
          99.55%
          Solubility
          insoluble in H2O; ≥15.1 mg/mL in DMSO; ≥24.2 mg/mL in EtOH with gentle warming
          Storage
          Store at -20°C

          * For Research Use Only

      • Reference

        • 1. Liu L, Li H, et al. "Involvement of CaMKII in regulating the release of diplotene-arrested mouse oocytes by pAkt1 (Ser473)." Cell Cycle. 2019 Sep 18:1-12. PMID:31530151

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