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Overview
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Kigamicin C was discovered by an anti-austerity strategy, targeting cancer cells' tolerance to starvation. It selectively kills PANC-1 cells (a pancreatic cell line) at concentrations 100 times lower under nutrient starved conditions than in normal conditions. It is active in vivo against a human pancreatic cancer xenograft model. Kigamicin C also inhibits the growth of Gram positive bacteria including MRSA, but is not active against Gram negative bacteria.
Kigamicin C is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.Please contact us at for specific academic pricing.
Background
The mechanism of action is proposed to be via blockade of aPKB/Akt activation, caused by the withdrawal of nutrients.
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- Properties
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Overview
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