Kidney Injury Panel 1 Rat Kit

The Kidney Injury Panel 1 (rat) Kit provides the assay-specific components for the quantitative determination of both natural and recombinant rat NGAL/LCN2 (neutrophil gelatinase-associated lipocalin; lipocalin-2), osteopontin (OPN), albumin, and HAVCR1/KIM-1 (hepatitis A virus cellular receptor 1; kidney injury molecule 1) also known as TIM-1 (T cell immunoglobulin- and mucin domain-containing molecule 1) in urine samples.

NGAL/LCN2 is a 25 kDa glycoprotein that acts as a transport protein carrying small hydrophobic molecules such as steroid hormones, vitamins, and metabolic products. It is expressed in most tissues and is induced in epithelial cells upon inflammation. In the kidney, NGAL/LCN2 may be implicated in both the progress of and protection from renal injury. OPN is a secreted acidic and phosphorylated glycoprotein that is involved in bone metabolism, immune regulation, cell survival, and tumor progression. OPN is mostly expressed in bone, kidney, and epithelial tissues. Albumin is the most abundant serum protein and acts as a transport protein for hemin and fatty acids. Albumin is produced in the liver and secreted into the bloodstream. HAVCR1/KIM-1 is a type 1 transmembrane glycoprotein found on CD4+ T cells and renal proximal tubule epithelial cells. HAVCR1/KIM-1 is released upon certain types of acute kidney, and can be measured in urine, serum, or plasma.

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Background

T-PLEX assay kits provide a rapid and convenient method for measuring the levels of biomarkers within a single, small-volume sample. The assays are available in both individual and multiplex formats. T-PLEX assay kits are research grade assays that are grouped into tissue culture, ultra-sensitive, whole cell lysate, serum/plasma, and base kits.

· Benefits: Analyzes protein levels from many sample types with a single assay. Improved analytical performance
· Format: Kits
· Multiplex: Compatible panels
· Sample compatibility: Secreted biomarker assays tested with serum, plasma, and cell culture supernatants; Intracellular assays tested with cell lysates